BILIRUBIN āϏāĻŽাāĻাāϰđŖđŖ _
Topics : #BILIRUBIN āϏāĻŽাāĻাāϰđŖđŖ
_
External : āύাāĻŽ āĻি ?āĻŦāϞিāϰ āĻĒাāĻ া Student : āĻাāϞিāĻĻাāϏ đ
External : āĻāĻšেāύ āĻāĻŦি āĻাāϞিāĻĻাāϏ , Obstructive jaundice āĻāĻŽাāĻĻেāϰ āĻšাāĻুāϰ đŠ colour āϏাāĻĻা (pale) āĻেāύ āĻšā§ে āϝাā§?
Student : đđ(āĻāĻāϤ্āϤ āĻĒাāĻāĻি āĻāĻāĻা common question… āĻāĻāĻŦাāϰ āĻĸেāϞে āĻĻিāĻŦ āĻāĻāĻĻāĻŽ ☕☕)
-
Sir, It is due to lack of #STERCOBILONOGEN.đ
_
External : Good . āĻāĻāύ āĻŦāϞ Stercobilinogen āĻি?đŧ
_
Student : Conjugated bilirubin , Intestine āĻ āĻāϏে Deconjugated āĻšā§ে urobilinogen āϤৈāϰি āĻāϰে। āĻāĻ urobilinogen āĻ Stercobilinogen āĻ convert āĻšā§ intestinal bacteria āĻāϰ āϏাāĻšাāϝ্āϝে।đ¸
_
External :đŧ āĻāĻ্āĻা āϤুāĻ āϝে āĻŦāϞāϞি Conjugated bilirubin āĻāϰ āĻāĻĨা āĻāĻāĻা āĻāĻĨ্āĻĨেāĻে āĻāϏāϞ?
_
Student : ( đ˛đ˛āĻŦ্āϝাāĻা āĻĒুāϰো bilirubin metabolism āĻāĻŽাāĻে āĻŦāϞাā§ে āĻাā§āĻŦে āĻŦুāĻāϤে āĻĒাāϰāĻি… āĻি āĻāϰ āĻāϰাāϰ āĻāĻŽিāĻ āĻĸেāϞে āĻĻেāĻ āĻাā§েāϰ āĻাāĻĒে āĻা āĻĸাāϞাāϰ āĻŽāϤđ☕)
-
Hemoglobin breakdown āĻšā§ে āϝে heme āϤৈāϰি āĻšā§ āĻāĻ heme⏩⏩ , Heme oxygenase enzyme āĻāϰ āϏাāĻšাāϝ্āϝে Biliverdin āϤৈāϰি āĻāϰে।⏩⏩āĻĒāϰে āĻāĻ Biliverdin , Biliverdin reductase enzyme āĻāϰ āϏাāĻšাāϝ্āϝে Unconjugated bilirubin āϤৈāϰি āĻāϰে⏩⏩ āϝা liver āĻ āĻāϏে hepatocytes āĻ Conjugation āĻšā§ with Glucoronic acid by Glucoronyl transferase enzyme and Conjugated bilirubin āϤৈāϰি āĻšā§।đđđđđ
External :đąđą āĻŦাঃ āĻŦাāĻেāϰ āĻŦাāĻ্āĻা । āĻāĻāύ āϤাāĻšāϞে āĻŦāϞ āĻোāύ āĻোāύ condition āĻ b conjugated and unconjgated bilirubin āĻŦাā§ে?
_
Student : Sir #Unconjugated_Bilirubin , liver āĻ āĻāϏে conjugated āĻšā§ liver āĻ āĻোāύ proble āĻĨাāĻāϞে āĻŦা āĻোāύ āĻাāϰāĻŖে āϝāĻĻি RBC āĻŦেāĻļি āĻŦেāĻļি breakdown āĻšā§ āϤাāĻšāϞে #unconjugated_bilirubin āĻŦাā§āĻŦে⤴⤴⤴ .
- #Hemolytic_jaundice
- #Gilbert_syndrome ( low hepatic uptake of unc. Bilirubin)
- #Crigler_najjar_syndrome (deficiency or absence of Glucoronyl transferase enzyme)
_
āĻāϰ āϏ্āϝাāϰ #conjugated_bilirubin āϤāĻāύ āĻ āĻŦাā§ে⤴⤴⤴ āϝāĻāύ billiary cuhannel āĻ āĻোāύ obstruction āĻāϰ āĻাāϰāĻŖে Bile āĻāϰ āϏাāĻĨে conjugated bilirubin āĻŦেāϰ āĻšāϤে āĻĒাāϰে āύা। āĻŽাāύে āϤāĻāύconjugated bilirubin , blood āĻ āĻāϞে āĻāϏে-
-#Obstructive_jaundice
-#Dubin_johnson_syndrome ( decreased hepatic excretion of conjugated bilirubin)
-#Rotors_syndrome ( decreased hepatic excretion of conjugated bilirubin)
Normally blood āĻ Unconjugated bilirubin āĻŦেāĻļি āĻĨাāĻে conjugated bilirubin āĻāϰ āĻেā§ে।
_
External : đ¯đ¯đ¯đ¯đ¯đ¯đ¯đ¯đ¯đ
-
Internal : āĻĻেāĻāĻেāύ sir , āĻāĻŽাāĻĻেāϰ āĻেāϞে āĻŽেā§েāϰা āĻāĻšিāϰ āĻাāĻā§েāϰ āĻāĻি āĻĒā§āϞেāĻ āĻŦুāĻে āĻĒā§ে। đđđđđ
External : āĻĻিā§ে āĻĻেāύ HONOURS…. āĻŦাāĻেāϰ āĻŦাāĻ্āĻাāĻে ।đ¯đ¯đ¯đ¯đ¯đ¯đ¯
No comments