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BILIRUBIN āϏāĻŽাāϚাāĻ°đŸ“ŖđŸ“Ŗ _

Topics : #BILIRUBIN  āϏāĻŽাāϚাāĻ°đŸ“ŖđŸ“Ŗ

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External : āύাāĻŽ āĻ•ি ?
 āĻŦāϞিāϰ āĻĒাāĻ া Student  : āĻ•াāϞিāĻĻাāϏ 😎
External : āĻ•āĻšেāύ āĻ•āĻŦি āĻ•াāϞিāĻĻাāϏ , Obstructive jaundice āφāĻŽাāĻĻেāϰ āĻšাāĻ—ুāϰ 💩 colour āϏাāĻĻা (pale) āĻ•েāύ āĻšā§Ÿে āϝা⧟?
Student : 😁😁(āĻāχāϤ্āϤ āĻĒাāχāĻ›ি āĻāĻ•āϟা common question… āĻāχāĻŦাāϰ āĻĸেāϞে āĻĻিāĻŦ āĻāĻ•āĻĻāĻŽ  ☕☕)
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Sir, It is due to lack of #STERCOBILONOGEN.😎
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External : Good . āĻāĻ–āύ āĻŦāϞ Stercobilinogen  āĻ•ি?đŸ˜ŧ
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Student : Conjugated bilirubin , Intestine āĻ āĻāϏে Deconjugated  āĻšā§Ÿে urobilinogen āϤৈāϰি āĻ•āϰে। āĻāχ urobilinogen āχ  Stercobilinogen āĻ convert āĻšā§Ÿ intestinal bacteria  āĻāϰ āϏাāĻšাāϝ্āϝে।😸
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External :đŸ˜ŧ āφāϚ্āĻ›া āϤুāχ āϝে āĻŦāϞāϞি Conjugated bilirubin āĻāϰ āĻ•āĻĨা āĻāχāϟা āĻ•āĻĨ্āĻĨেāĻ•ে āφāϏāϞ?
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Student : ( 😲😲āĻŦ্āϝাāϟা āĻĒুāϰো bilirubin metabolism āφāĻŽাāĻ•ে āĻŦāϞা⧟ে āĻ›া⧜āĻŦে āĻŦুāĻāϤে āĻĒাāϰāĻ›ি… āĻ•ি āφāϰ āĻ•āϰাāϰ āφāĻŽিāĻ“ āĻĸেāϞে āĻĻেāχ āϚা⧟েāϰ āĻ•াāĻĒে āϚা āĻĸাāϞাāϰ āĻŽāĻ¤đŸ˜☕)
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Hemoglobin breakdown āĻšā§Ÿে āϝে  heme āϤৈāϰি āĻšā§Ÿ āĻāχ heme⏩⏩ , Heme oxygenase enzyme āĻāϰ āϏাāĻšাāϝ্āϝে Biliverdin āϤৈāϰি āĻ•āϰে।⏩⏩āĻĒāϰে āĻāχ Biliverdin , Biliverdin reductase enzyme āĻāϰ āϏাāĻšাāϝ্āϝে Unconjugated bilirubin āϤৈāϰি āĻ•āϰে⏩⏩ āϝা  liver āĻ āĻāϏে hepatocytes āĻ Conjugation āĻšā§Ÿ with Glucoronic acid by Glucoronyl transferase enzyme and  Conjugated bilirubin  āϤৈāϰি  āĻšā§Ÿ।😎😎😎😎😎
External :😱😱 āĻŦাঃ āĻŦাāϘেāϰ āĻŦাāϚ্āϚা । āĻāĻ–āύ āϤাāĻšāϞে āĻŦāϞ āĻ•োāύ āĻ•োāύ  condition āĻ b conjugated and unconjgated bilirubin āĻŦা⧜ে?
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 Student : Sir #Unconjugated_Bilirubin , liver āĻ āĻāϏে conjugated  āĻšā§Ÿ liver āĻ āĻ•োāύ proble āĻĨাāĻ•āϞে āĻŦা āĻ•োāύ āĻ•াāϰāĻŖে āϝāĻĻি RBC āĻŦেāĻļি āĻŦেāĻļি breakdown āĻšā§Ÿ āϤাāĻšāϞে #unconjugated_bilirubin āĻŦা⧜āĻŦে⤴⤴⤴ .
- #Hemolytic_jaundice
- #Gilbert_syndrome ( low hepatic uptake of unc. Bilirubin)
- #Crigler_najjar_syndrome (deficiency or absence of Glucoronyl transferase enzyme)
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āφāϰ āϏ্āϝাāϰ  #conjugated_bilirubin āϤāĻ–āύ āχ āĻŦা⧜ে⤴⤴⤴ āϝāĻ–āύ billiary cuhannel āĻ āĻ•োāύ obstruction āĻāϰ āĻ•াāϰāĻŖে Bile āĻāϰ āϏাāĻĨে conjugated bilirubin āĻŦেāϰ āĻšāϤে āĻĒাāϰে āύা। āĻŽাāύে āϤāĻ–āύconjugated bilirubin , blood  āĻ āϚāϞে āφāϏে-
-#Obstructive_jaundice
-#Dubin_johnson_syndrome ( decreased hepatic excretion of conjugated bilirubin)
-#Rotors_syndrome ( decreased hepatic excretion of conjugated bilirubin)
Normally blood āĻ  Unconjugated bilirubin āĻŦেāĻļি āĻĨাāĻ•ে  conjugated bilirubin āĻāϰ āϚে⧟ে।
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External : đŸ˜¯đŸ˜¯đŸ˜¯đŸ˜¯đŸ˜¯đŸ˜¯đŸ˜¯đŸ˜¯đŸ˜¯đŸ˜‘
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Internal : āĻĻেāĻ–āĻ›েāύ sir , āφāĻŽাāĻĻেāϰ āĻ›েāϞে āĻŽে⧟েāϰা āϜāĻšিāϰ āĻ­াāĻ‡ā§Ÿেāϰ āϚāϟি āĻĒ⧜āϞেāĻ“ āĻŦুāĻে āĻĒ⧜ে। 😄😄😄😄😄
External : āĻĻি⧟ে āĻĻেāύ HONOURS…. āĻŦাāϘেāϰ āĻŦাāϚ্āϚাāĻ•ে ।đŸ¯đŸ¯đŸ¯đŸ¯đŸ¯đŸ¯đŸ¯

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