āĻĒ্āĻ°āĻĢেāĻ°_āĻাāĻāĻŦাā§_Sero_Negative_Spondyloarthiritis
#āĻĒ্āĻ°āĻĢেāĻ°_āĻাāĻāĻŦাā§_Sero_Negative_Spondyloarthiritis ❤️
đ¨đģ⚕️: Seronegative spondyloarthritis āĻāĻ° āĻ¨াāĻŽ āĻļুāĻ¨েāĻিāĻ¸?āĻŦāĻ˛āĻ¤ে āĻĒাāĻ°āĻŦি āĻāĻাāĻে āĻেāĻ¨ Sero negative āĻŦāĻ˛া āĻšā§?
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° Sero āĻļāĻŦ্āĻĻ āĻা #Serum āĻĨেāĻে āĻāĻ¸āĻে! āĻ¸াāĻ§াāĻ°āĻ¨āĻ¤ āĻŦেāĻļিāĻ° āĻাāĻ Arthritis āĻāĻ° patient āĻĻেāĻ° Serum āĻ Rheumatoid Factor ( RF ) āĻĒাāĻā§া āĻ¯াā§। RF āĻা āĻšāĻ˛ো Antibody against Fc portion of IgG !
āĻāĻাāĻ¨ে Ab-Ab complex āĻ¤ৈāĻ°ী āĻšā§। āĻāĻŦং complement activation āĻšā§ে damage āĻāĻ°ে joint āĻāĻŦং āĻ āĻ¨্āĻ¯াāĻ¨্āĻ¯ Organ ! āĻ¯েāĻŽāĻ¨: Rheumatoid Arthritis , SLE āĻāĻুāĻ˛ো āĻ¤ে joint pain āĻāĻ° patient āĻĻেāĻ° RF, blood āĻ āĻĒাāĻā§া āĻ¯াā§। āĻিāĻ¨্āĻ¤ু āĻিāĻু Arthritis āĻāĻ° āĻ°োāĻীāĻĻেāĻ° Blood āĻ āĻŦা Serum āĻ RF āĻĒাāĻā§া āĻ¯াā§ āĻ¨া!āĻāĻŦং āĻ¤াāĻĻেāĻ° āĻিāĻু common features āĻĨাāĻে।
āĻāĻĻেāĻ° āĻāĻāĻ¤্āĻ°ে Seronegative Spondyloarthritis āĻŦāĻ˛ে।
đ¨đģ⚕️: Thats Good ! Sero negative arthritis āĻুāĻ˛োāĻ° āĻ¨াāĻŽ āĻŦāĻ˛āĻ¤ে āĻĒাāĻ°āĻŦি?
đŠđģ⚕️: āĻি āĻ¸্āĻ¯াāĻ°! āĻ¤াāĻĻেāĻ° āĻ¨াāĻŽ āĻšāĻ˛ো āĻ¨াāĻļāĻĒাāĻ¤ি āĻŦা PEAR đ
đ¨đģ⚕️: āĻি āĻ¤োāĻ° āĻāĻ¤ āĻŦā§ āĻ¸াāĻšāĻ¸! āĻাāĻāĻŦা āĻŦোāĻ°্āĻĄে āĻĢাāĻāĻ˛াāĻŽি?đĄPEAR āĻāĻ¸āĻ˛ো āĻোāĻĨা āĻĨেāĻে?
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° "#PEAR "stands for
P - #Psoriatic Arthritis
E -#Enteropathy associated Arthritis (IBD )
A - #Ankylosing_Spondylitis
R - #Reactive_Arthritis
đ¨đģ⚕️: āĻ¯াāĻ āĻŦেāĻে āĻেāĻ˛ি! āĻāĻ°āĻĒāĻ°েāĻ° āĻŦাāĻ° āĻŽাāĻĢ āĻ¨েāĻ! āĻ িāĻ āĻāĻে āĻāĻĻেāĻ° common features āĻুāĻ˛া āĻি āĻি?
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° āĻāĻĻেāĻļ ( AADEESH )āĻāĻ°েāĻ¨ āĻŦāĻ˛ি!đ
đ¨đģ⚕️: āĻāĻŦাāĻ° āĻĢাāĻāĻ˛াāĻŽো? āĻāĻŽাāĻ° āĻāĻĨাāĻ āĻ¤ো āĻāĻĻেāĻļ! āĻŦāĻ˛ clinical Features āĻুāĻ˛ো!
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° āĻāĻĻেāĻļ ( #AADEESH ) stands for
A - #Axial joint involvement ( v. column )
A -#Asmymmetrical Oligo arthritis
D -#Dactylitis ( inflammation of Finger )
E - #Enthesitis
E -#Extraarticular Features
S - #Seronegativity
H - #HLA B27 gene present
đ¨đģ⚕️: āĻŦāĻšুāĻ¤ āĻুāĻŦ!! Asymmetrical Oligo Arthritis āĻŦ্āĻ¯াāĻĒাāĻ° āĻা āĻি?
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° āĻ¯āĻĻি āĻেāĻŦāĻ˛ āĻŽাāĻ¤্āĻ° 2-4 āĻা joint involve āĻšā§ āĻ¤āĻŦে āĻ¤াāĻে Oligo arthritis āĻŦāĻ˛ে। āĻāĻ° Arthritis āĻāĻ° āĻ¯āĻĻি āĻোāĻ¨ similar pattern āĻ¨া āĻĨাāĻে। āĻ¯েāĻŽāĻ¨ āĻ§āĻ°ুāĻ¨ āĻŦাāĻŽ āĻšাāĻ¤েāĻ° wrist āĻিāĻ¨্āĻ¤ু āĻĄাāĻ¨ āĻšাāĻ¤েāĻ° Elbow āĻŦ্āĻ¯াāĻĨা । āĻāĻ āĻুāĻ˛ো āĻে āĻŦāĻ˛ে #Asymmetrical ! RA āĻ āĻāĻŦাāĻ° Symmetrical poly arthritis āĻšā§!
đ¨đģ⚕️: very Good ! What about #Enthesitis ?
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° Tendor āĻāĻ° ligaments ,Bones āĻāĻ° āĻ¯ে āĻাā§āĻাā§ insertion āĻ¨েā§ āĻ¸েāĻ āĻাā§āĻা āĻে āĻŦāĻ˛ে #Entheses ! āĻāĻ Entheses āĻāĻ° Inflammation āĻেāĻ Enthesitis āĻŦāĻ˛ে!
đ¨đģ⚕️: āĻāĻ°ে āĻŦাāĻš! āĻāĻ āĻŽেā§েāĻ¤ো āĻĒুāĻ°া āĻāĻুāĻ¨!#Dactylitis āĻŽাāĻ¨ে āĻি?
đŠđģ⚕️: Inflammation of a Digit or Finger ! āĻāĻাāĻ° āĻāĻ°েāĻ āĻ¨াāĻŽ #Sausage_Digit ! āĻংāĻুāĻ˛ āĻĢুāĻ˛ে āĻāĻ˛া āĻাāĻ āĻšā§ে āĻ¯াā§ , āĻāĻŦং āĻ¸াāĻĨে āĻĨাāĻে āĻĒ্āĻ°āĻāĻ¨্āĻĄ āĻŦ্āĻ¯াāĻĨা!
đ¨đģ⚕️: āĻāĻ্āĻা āĻি āĻি extra articular āĻĢিāĻাāĻ° āĻĒাāĻā§া āĻ¯াā§ SN arthritis āĻ!
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° āĻ¸াāĻ§াāĻ°āĻ¨āĻ¤ āĻোāĻে #Uveitis āĻ¨িā§ে āĻāĻ¸ে!
Lung āĻ #Fibrosis āĻ¨িā§ে āĻāĻ¸ে। Heart āĻ Aortic root Dilatation āĻāĻŦং Block āĻ¨িā§ে āĻāĻ¸ে! āĻāĻাā§া Amylodosis āĻāĻŦং #Hepatosplenomegaly āĻ āĻĻেāĻা āĻ¯াā§।
đ¨đģ⚕️: HLA B27 āĻāĻ° āĻ¸āĻŽ্āĻĒāĻ°্āĻ āĻি āĻāĻাāĻ° āĻ¸াāĻĨে। Axial joint āĻāĻ° āĻŦ্āĻ¯াāĻĒাāĻ° āĻাāĻ āĻŦা āĻি?
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° āĻāĻা āĻāĻāĻা Gene ! āĻ¯েāĻা āĻ¸াāĻ§াāĻ°āĻ¨āĻ¤ Seronegative Arthritis āĻুāĻ˛ো āĻ¤ে āĻĒাāĻā§া āĻ¯াā§! āĻāĻ° Axial joint āĻŦāĻ˛āĻ¤ে vertebral column āĻāĻ° joint involvement āĻে āĻŦোāĻাā§!
đ¨đģ⚕️: Good āĻ¸ংāĻ্āĻˇেāĻĒে Treatment āĻŦāĻ˛ে Honours āĻ¨িā§ে āĻāĻ˛ে āĻ¯া।
đŠđģ⚕️: Pain āĻāĻ° āĻāĻ¨্āĻ¯ āĻāĻāĻা #NSAID āĻĻিāĻŦ āĻāĻŽāĻ°া!
āĻāĻ° prognosis āĻাāĻ˛ āĻāĻ°াāĻ° āĻāĻ¨্āĻ¯ #DMARD āĻĻিāĻŦ!
đ¨đģ⚕️: just Super ! āĻāĻ¤ āĻিāĻু āĻĒাāĻ°িāĻ¸ āĻিāĻাāĻŦে? āĻ¸āĻাāĻ˛ে āĻ¤ো āĻĻেāĻāĻ˛াāĻŽ āĻŦাāĻ¨্āĻ§িāĻŦী āĻে āĻŦāĻ˛āĻ¤েāĻিāĻ¸ , " āĻĻোāĻ¸্āĻ¤ āĻিāĻু āĻĒāĻ°িāĻ¨াāĻ! āĻāĻ sure fail !!
đŠđģ⚕️: āĻ¸্āĻ¯াāĻ° āĻāĻা āĻāĻŽাāĻ° āĻ āĻ্āĻ¯াāĻ¸ đŦđŦ!
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