BILIRUBIN āĻ¸āĻŽাāĻাāĻ°đŖđŖ _
Topics : #BILIRUBIN āĻ¸āĻŽাāĻাāĻ°đŖđŖ
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External : āĻ¨াāĻŽ āĻি ?āĻŦāĻ˛িāĻ° āĻĒাāĻ া Student : āĻাāĻ˛িāĻĻাāĻ¸ đ
External : āĻāĻšেāĻ¨ āĻāĻŦি āĻাāĻ˛িāĻĻাāĻ¸ , Obstructive jaundice āĻāĻŽাāĻĻেāĻ° āĻšাāĻুāĻ° đŠ colour āĻ¸াāĻĻা (pale) āĻেāĻ¨ āĻšā§ে āĻ¯াā§?
Student : đđ(āĻāĻāĻ¤্āĻ¤ āĻĒাāĻāĻি āĻāĻāĻা common question… āĻāĻāĻŦাāĻ° āĻĸেāĻ˛ে āĻĻিāĻŦ āĻāĻāĻĻāĻŽ ☕☕)
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Sir, It is due to lack of #STERCOBILONOGEN.đ
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External : Good . āĻāĻāĻ¨ āĻŦāĻ˛ Stercobilinogen āĻি?đŧ
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Student : Conjugated bilirubin , Intestine āĻ āĻāĻ¸ে Deconjugated āĻšā§ে urobilinogen āĻ¤ৈāĻ°ি āĻāĻ°ে। āĻāĻ urobilinogen āĻ Stercobilinogen āĻ convert āĻšā§ intestinal bacteria āĻāĻ° āĻ¸াāĻšাāĻ¯্āĻ¯ে।đ¸
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External :đŧ āĻāĻ্āĻা āĻ¤ুāĻ āĻ¯ে āĻŦāĻ˛āĻ˛ি Conjugated bilirubin āĻāĻ° āĻāĻĨা āĻāĻāĻা āĻāĻĨ্āĻĨেāĻে āĻāĻ¸āĻ˛?
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Student : ( đ˛đ˛āĻŦ্āĻ¯াāĻা āĻĒুāĻ°ো bilirubin metabolism āĻāĻŽাāĻে āĻŦāĻ˛াā§ে āĻাā§āĻŦে āĻŦুāĻāĻ¤ে āĻĒাāĻ°āĻি… āĻি āĻāĻ° āĻāĻ°াāĻ° āĻāĻŽিāĻ āĻĸেāĻ˛ে āĻĻেāĻ āĻাā§েāĻ° āĻাāĻĒে āĻা āĻĸাāĻ˛াāĻ° āĻŽāĻ¤đ☕)
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Hemoglobin breakdown āĻšā§ে āĻ¯ে heme āĻ¤ৈāĻ°ি āĻšā§ āĻāĻ heme⏩⏩ , Heme oxygenase enzyme āĻāĻ° āĻ¸াāĻšাāĻ¯্āĻ¯ে Biliverdin āĻ¤ৈāĻ°ি āĻāĻ°ে।⏩⏩āĻĒāĻ°ে āĻāĻ Biliverdin , Biliverdin reductase enzyme āĻāĻ° āĻ¸াāĻšাāĻ¯্āĻ¯ে Unconjugated bilirubin āĻ¤ৈāĻ°ি āĻāĻ°ে⏩⏩ āĻ¯া liver āĻ āĻāĻ¸ে hepatocytes āĻ Conjugation āĻšā§ with Glucoronic acid by Glucoronyl transferase enzyme and Conjugated bilirubin āĻ¤ৈāĻ°ি āĻšā§।đđđđđ
External :đąđą āĻŦাঃ āĻŦাāĻেāĻ° āĻŦাāĻ্āĻা । āĻāĻāĻ¨ āĻ¤াāĻšāĻ˛ে āĻŦāĻ˛ āĻোāĻ¨ āĻোāĻ¨ condition āĻ b conjugated and unconjgated bilirubin āĻŦাā§ে?
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Student : Sir #Unconjugated_Bilirubin , liver āĻ āĻāĻ¸ে conjugated āĻšā§ liver āĻ āĻোāĻ¨ proble āĻĨাāĻāĻ˛ে āĻŦা āĻোāĻ¨ āĻাāĻ°āĻŖে āĻ¯āĻĻি RBC āĻŦেāĻļি āĻŦেāĻļি breakdown āĻšā§ āĻ¤াāĻšāĻ˛ে #unconjugated_bilirubin āĻŦাā§āĻŦে⤴⤴⤴ .
- #Hemolytic_jaundice
- #Gilbert_syndrome ( low hepatic uptake of unc. Bilirubin)
- #Crigler_najjar_syndrome (deficiency or absence of Glucoronyl transferase enzyme)
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āĻāĻ° āĻ¸্āĻ¯াāĻ° #conjugated_bilirubin āĻ¤āĻāĻ¨ āĻ āĻŦাā§ে⤴⤴⤴ āĻ¯āĻāĻ¨ billiary cuhannel āĻ āĻোāĻ¨ obstruction āĻāĻ° āĻাāĻ°āĻŖে Bile āĻāĻ° āĻ¸াāĻĨে conjugated bilirubin āĻŦেāĻ° āĻšāĻ¤ে āĻĒাāĻ°ে āĻ¨া। āĻŽাāĻ¨ে āĻ¤āĻāĻ¨conjugated bilirubin , blood āĻ āĻāĻ˛ে āĻāĻ¸ে-
-#Obstructive_jaundice
-#Dubin_johnson_syndrome ( decreased hepatic excretion of conjugated bilirubin)
-#Rotors_syndrome ( decreased hepatic excretion of conjugated bilirubin)
Normally blood āĻ Unconjugated bilirubin āĻŦেāĻļি āĻĨাāĻে conjugated bilirubin āĻāĻ° āĻেā§ে।
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External : đ¯đ¯đ¯đ¯đ¯đ¯đ¯đ¯đ¯đ
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Internal : āĻĻেāĻāĻেāĻ¨ sir , āĻāĻŽাāĻĻেāĻ° āĻেāĻ˛ে āĻŽেā§েāĻ°া āĻāĻšিāĻ° āĻাāĻā§েāĻ° āĻāĻি āĻĒā§āĻ˛েāĻ āĻŦুāĻে āĻĒā§ে। đđđđđ
External : āĻĻিā§ে āĻĻেāĻ¨ HONOURS…. āĻŦাāĻেāĻ° āĻŦাāĻ্āĻাāĻে ।đ¯đ¯đ¯đ¯đ¯đ¯đ¯
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